Efficacy of penbutolol and a fixed combination of penbutolol with furosemide in the treatment of hypertension
In an open multi-centre study, 51 patients with mild to moderate hypertension were treated with either a single dose of 40 mg penbutolol per day for 8 weeks or changed over at 4 weeks due to inadequate response with penbutolol alone to a single dose (1 tablet) of a fixed combination of 40 mg penbuto...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 3(1982), 4 vom: 12., Seite 233-42 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1982
|
| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Journal Article Drug Combinations Propanolamines Penbutolol 78W62V43DY Furosemide 7LXU5N7ZO5 |
| Zusammenfassung: | In an open multi-centre study, 51 patients with mild to moderate hypertension were treated with either a single dose of 40 mg penbutolol per day for 8 weeks or changed over at 4 weeks due to inadequate response with penbutolol alone to a single dose (1 tablet) of a fixed combination of 40 mg penbutolol and 20 mg furosemide per day for a further 4 weeks. Thirty-six (70%) of the patients showed an adequate reduction in diastolic blood pressure to 95 mmHg or less on penbutolol alone. Of the 15 patients who did not show the desired response to penbutolol alone, 13 (86.7%) showed a satisfactory reduction in blood pressure after 4 weeks on the combination product; 2 of these patients had received 1 tablet twice daily from Week 6 of treatment. Two other patients received 1 tablet of the combination twice daily from Week 8 onwards for 2 weeks. Only 1 of them did not respond to this therapy. Blood pressure reduction and weight loss were significantly greater on the combination product than on penbutolol alone. No clinically significant changes were noted in serum potassium, glucose, creatinine or uric acid levels, and mild gastric side-effects at the beginning of treatment were reported in only 3 patients, 1 of whom was also receiving indomethacin |
|---|---|
| Beschreibung: | Date Completed 07.01.1983 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |