A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa

An open crossover study was carried out in 10 Arab patients with mild to moderate hypertension to compare the effectiveness and tolerability of labetalol with alpha-methyldopa. Patients were started on either 100 mg labetalol or 250 mg alpha-methyldopa 3-times daily and, if necessary, the dosage adj...

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Bibliographische Detailangaben
Veröffentlicht in:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 3(1982), 2 vom: 13., Seite 133-9
1. Verfasser: Al-Damluji, S F (VerfasserIn)
Weitere Verfasser: Al-Khalidi, A, Shaarbaf, H, Tawfiq, N H
Format: Aufsatz
Sprache:English
Veröffentlicht: 1982
Zugriff auf das übergeordnete Werk:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
Schlagworte:Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial Ethanolamines Methyldopa 56LH93261Y Labetalol R5H8897N95
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245 1 2 |a A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa 
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520 |a An open crossover study was carried out in 10 Arab patients with mild to moderate hypertension to compare the effectiveness and tolerability of labetalol with alpha-methyldopa. Patients were started on either 100 mg labetalol or 250 mg alpha-methyldopa 3-times daily and, if necessary, the dosage adjusted by standard increments every 2 weeks over a period of a month until satisfactory control was achieved. This dosage was then maintained for a further 6 weeks before the patients were crossed over to the alternative treatment, similarly adjusted, after a wash-out period of 2 weeks on placebo. The results showed that both treatments produced effective blood pressure control and there was no significant difference in the maximum reduction achieved. The effect of the two drugs on heart rate was also similar. Both treatments were generally well-tolerated and side-effects were mild and similar with either drug 
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650 4 |a Comparative Study 
650 4 |a Controlled Clinical Trial 
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650 4 |a Randomized Controlled Trial 
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700 1 |a Shaarbaf, H  |e verfasserin  |4 aut 
700 1 |a Tawfiq, N H  |e verfasserin  |4 aut 
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