Prospective double-blind controlled clinical study of sisomicin versus tobramycin
A double-blind controlled trial was carried out to compare the efficacy of sisomicin and tobramycin in the treatment of 55 hospitalized patients with serious systemic infections, mostly intra-abdominal or soft-tissue infections. Each drug was administered intramuscularly or intravenously at a dosage...
| Publié dans: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 2(1981), 8 vom: 16., Seite 499-503 |
|---|---|
| Auteur principal: | |
| Autres auteurs: | |
| Format: | Article |
| Langue: | English |
| Publié: |
1981
|
| Accès à la collection: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Sujets: | Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Anti-Bacterial Agents Gentamicins Tobramycin VZ8RRZ51VK Sisomicin X55XSL74YQ |
| Résumé: | A double-blind controlled trial was carried out to compare the efficacy of sisomicin and tobramycin in the treatment of 55 hospitalized patients with serious systemic infections, mostly intra-abdominal or soft-tissue infections. Each drug was administered intramuscularly or intravenously at a dosage of 2.5 to 4.0 mg/kg per day for between 5 and 21 days. At the end of treatment, 22 (79%) of 28 sisomicin-treated patients and 15 (72%) of 21 tobramycin-treated patients were assessed, on the basis of clinical and bacteriological response, as cured or partially cured. Sisomicin was superior in the treatment of Escherichia coli infections. Local tolerance to both drugs was good. The incidence of systemic adverse reactions was low, fewer cases occurring in the sisomicin treatment group than in the tobramycin treatment group |
|---|---|
| Description: | Date Completed 25.09.1981 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |