An evaluation of the short-term hypnotic efficacy of loprazolam in comparison with nitrazepam in elderly patients

A double-blind, parallel group, randomized trial was carried out to compare the hypnotic efficacy of 1.0 mg loprazolam and 5.0 mg nitrazepam in 40 elderly patients. All had disturbed sleep patterns, which were not the result of physical illness, and had been shown to be placebo non-responders during...

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Veröffentlicht in:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 3(1983), 7 vom: 22., Seite 468-74
1. Verfasser: Bayer, A J (VerfasserIn)
Weitere Verfasser: Pathy, M S, Ankier, S I
Format: Aufsatz
Sprache:English
Veröffentlicht: 1983
Zugriff auf das übergeordnete Werk:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
Schlagworte:Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Anti-Anxiety Agents Benzodiazepinones Benzodiazepines 12794-10-4 triazulenone 759N8462G8 mehr... Nitrazepam 9CLV70W7HS
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245 1 3 |a An evaluation of the short-term hypnotic efficacy of loprazolam in comparison with nitrazepam in elderly patients 
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520 |a A double-blind, parallel group, randomized trial was carried out to compare the hypnotic efficacy of 1.0 mg loprazolam and 5.0 mg nitrazepam in 40 elderly patients. All had disturbed sleep patterns, which were not the result of physical illness, and had been shown to be placebo non-responders during a 3-day placebo screening period. Patients received active medication for 7 nights. Both loprazolam and nitrazepam significantly improved sleep patterns, as measured by patient self-rating scales and night nurses' global assessments, in comparison with the placebo baseline screen (p less than 0.001). No significant differences in efficacy were shown between drug treatments and no untoward effects were recorded which could be attributed to either drug. The results suggest that 1.0 mg loprazolam is an effective and well-tolerated hypnotic in elderly patients suffering from insomnia 
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650 4 |a Comparative Study 
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700 1 |a Pathy, M S  |e verfasserin  |4 aut 
700 1 |a Ankier, S I  |e verfasserin  |4 aut 
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