Ketotifen in the oral prophylaxis of bronchial asthma : a review
The experimental data providing the rationale for the use of ketotifen as a prophylactic drug in asthma (inhibition of release of the mediators of anaphylaxis, particularly SRS-A, prevention of the bronchospasm induced by SRS-A in vivo, calcium antagonist effect) are briefly discussed, and the resul...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 3(1981), 1 vom: 24., Seite 18-35 |
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| 1. Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1981
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Journal Article Review Histamine H1 Antagonists Irritants Theophylline C137DTR5RG Cromolyn Sodium Q2WXR1I0PK Ketotifen X49220T18G |
| Zusammenfassung: | The experimental data providing the rationale for the use of ketotifen as a prophylactic drug in asthma (inhibition of release of the mediators of anaphylaxis, particularly SRS-A, prevention of the bronchospasm induced by SRS-A in vivo, calcium antagonist effect) are briefly discussed, and the results of experimental and therapeutic trials carried out over 6 years in a number of countries in several thousand patients are reviewed. Some important features of oral asthma prophylaxis with ketotifen are underlined, namely the effect of ketotifen on the characteristic bronchial hyperreactivity of asthma, the types of asthma which respond best to ketotifen treatment, the effect of ketotifen in reducing the concomitant use of corticosteroids and bronchodilators, a comparison of ketotifen with specific antihistamines, theophylline derivatives and sodium cromoglycate, and the side-effects and long-term safety of ketotifen |
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| Beschreibung: | Date Completed 22.03.1982 Date Revised 19.11.2015 published: Print Citation Status MEDLINE |