Diabetic retinal vascular complications and erythrocyte filtrability; results of a 2-year follow-up study with pentoxifylline
A long-term trial with oral pentoxifylline ("Trental" 400) in a dosage of 1200 mg per day was carried out in 70 diabetic patients with and without vascular afflictions. A statistically significant improvement in erythrocyte filtrability and a statistically significant reduction in fibrinog...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 4(1985), 6 vom: 30., Seite 341-50 |
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| Format: | Aufsatz |
| Sprache: | English |
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1985
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Journal Article Blood Glucose Glycated Hemoglobin A Fibrinogen 9001-32-5 Theobromine OBD445WZ5P Pentoxifylline SD6QCT3TSU |
| Zusammenfassung: | A long-term trial with oral pentoxifylline ("Trental" 400) in a dosage of 1200 mg per day was carried out in 70 diabetic patients with and without vascular afflictions. A statistically significant improvement in erythrocyte filtrability and a statistically significant reduction in fibrinogen levels were observed after 2 months of therapy; the significant improvement in both parameters was maintained throughout the 24 months of treatment. Blood rheology normalization was followed by a marked reduction in proteinuria and albumin excretion rate. After pentoxifylline administration, an improvement in both microvascular and macrovascular afflictions was demonstrated. The results of this study suggest that pentoxifylline is an effective drug for the long-term treatment of diabetic vascular complications and that it may also possibly depress or prevent the progress of the disease |
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| Beschreibung: | Date Completed 14.02.1986 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |