Pregnancy-associated nonspecific immunosuppression : mechanism for the activation of the immunosuppressive factors
The nonspecific immunosuppressive effect observed in pregnancy sera and mediated by two factors, immunosuppressive factors (ISF) I and II, was regulated by a third molecule termed the pregnancy-depleted immunoregulatory factor (pdIRF). Natural depletion of serum pdIRF levels during pregnancy resulte...
| Veröffentlicht in: | Malignant potential of aneuploid pancreatic endocrine tumours. - 1993. - 9(1985), 3 vom: 15. Nov., Seite 84-90 |
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| Format: | Aufsatz |
| Sprache: | English |
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1985
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| Zugriff auf das übergeordnete Werk: | Malignant potential of aneuploid pancreatic endocrine tumours |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Immunoglobulin G Magnesium I38ZP9992A Calcium SY7Q814VUP |
| Zusammenfassung: | The nonspecific immunosuppressive effect observed in pregnancy sera and mediated by two factors, immunosuppressive factors (ISF) I and II, was regulated by a third molecule termed the pregnancy-depleted immunoregulatory factor (pdIRF). Natural depletion of serum pdIRF levels during pregnancy resulted in the activation of the ISF-I and ISF-II molecules, which prior to conception existed in the serum in inactive forms. The inactive ISF-I and ISF-II molecules in male sera and in nulliparous nonpregnant female sera can be activated following the artificial selective depletion of pdIRF by absorption onto Sephacryl S-300. It is proposed that inactive complexes consisting of the ISF-I and ISF-II molecules and pdIRF and possibly involving Ca2+ and Mg2+ ions are a feature of normal sera. The pdIRF molecule has an apparent Mr of 100,000-125,000 daltons and consists of a single major polypeptide of 63,000 daltons. Equal concentrations of pdIRF are present in male and female normal sera |
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| Beschreibung: | Date Completed 23.01.1986 Date Revised 03.12.2021 published: Print Citation Status MEDLINE |