Preliminary human pharmacokinetics of triletide
Six healthy volunteers were administered a single 1 g dose of triletide, orally, and blood concentrations of the parent drug determined by high pressure liquid chromatography over a 10-hour period. Analysis of both individual and pooled data indicated that triletide was well absorbed after oral admi...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 4(1985), 3 Spec No vom: 15., Seite 189-94 |
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| 1. Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1985
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Journal Article Anti-Ulcer Agents Oligopeptides triletide 50Q6LI773L |
| Zusammenfassung: | Six healthy volunteers were administered a single 1 g dose of triletide, orally, and blood concentrations of the parent drug determined by high pressure liquid chromatography over a 10-hour period. Analysis of both individual and pooled data indicated that triletide was well absorbed after oral administration, with a lag time of 0.3 hours and the blood peak was reached after about 1.1 to 1.3 hours. Metabolization to desmethyl, desacetyl, desmethyl-desacetyl and hydroxylated derivatives plays a major role in the biotransformation of the drug and thus in its disappearance from blood, the distribution half-life being about 1 hour. Elimination half-life ranged about 5 hours, thus suggesting a dosage schedule of 3-times daily for loading, while for maintenance a twice-daily schedule appears also suitable. The existence of deep compartments and, therefore, risks of accumulation appear to be excluded |
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| Beschreibung: | Date Completed 18.12.1985 Date Revised 15.11.2012 published: Print Citation Status MEDLINE |