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231221s1986 xx ||||| 00| ||jpn c |
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|a jpn
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1 |
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|a Sekine, H
|e verfasserin
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|a Double channel chemotherapy with intra-arterial infusion of DDP and concurrent intra-venous infusion of sodium thiosulfate (STS) in bladder cancer
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| 264 |
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1 |
|c 1986
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| 336 |
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|a Text
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|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
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| 338 |
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|a Date Completed 14.05.1986
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|a Date Revised 19.11.2015
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|a published: Print
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|a Citation Status MEDLINE
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|a Ten patients with bladder cancer were treated with double channel chemotherapy which included intra-arterial infusion of DDP and concurrent intra-venous infusion of STS, a neutralizing agent against DDP. The method allows the administration of a relatively high dose of DDP to localized malignant tumors by protection from systemic cytotoxicity of DDP by STS. DDP in a dose of 100-150 mg/m2 of body surface was infused either to the internal iliac artery at a portion close to the superior vesical artery or to the aortic bifurcation by the Seldinger technique over 30 minutes, and infusion of 20 g STS to the peripheral vein was simultaneously started and continued for 2-3 hours. One patient achieved a complete response and 2 patients achieved a partial response. The response rate was 30%. Histopathologically, 4 out of 8 patients showed an effect of 2 grades or more by Oboshi-Shimosato's criteria. Invasive or hypervascular tumors seem to be more responsive to the present treatment than superficial or hypovascular ones. Side effects were relatively mild inspite of a large dose of DDP. It should be noted that concurrent STS infusion efficiently counteracts the renal toxicity of DDP
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| 650 |
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Antidotes
|2 NLM
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| 650 |
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7 |
|a Thiosulfates
|2 NLM
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| 650 |
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|a sodium thiosulfate
|2 NLM
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| 650 |
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7 |
|a HX1032V43M
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| 650 |
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|a Cisplatin
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| 650 |
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| 700 |
1 |
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|a Yosida, T
|e verfasserin
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|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 32(1986), 1 vom: 01. Jan., Seite 43-8
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
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|g volume:32
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