|
|
|
|
LEADER |
01000naa a22002652 4500 |
001 |
NLM038850389 |
003 |
DE-627 |
005 |
20231221143907.0 |
007 |
tu |
008 |
231221s1985 xx ||||| 00| ||eng c |
028 |
5 |
2 |
|a pubmed24n0130.xml
|
035 |
|
|
|a (DE-627)NLM038850389
|
035 |
|
|
|a (NLM)3903787
|
040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
041 |
|
|
|a eng
|
100 |
1 |
|
|a Gandolfi, L
|e verfasserin
|4 aut
|
245 |
1 |
0 |
|a Triletide and ranitidine for the management of chronic duodenal ulcer
|b a controlled clinical investigation
|
264 |
|
1 |
|c 1985
|
336 |
|
|
|a Text
|b txt
|2 rdacontent
|
337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
500 |
|
|
|a Date Completed 18.12.1985
|
500 |
|
|
|a Date Revised 21.11.2013
|
500 |
|
|
|a published: Print
|
500 |
|
|
|a Citation Status MEDLINE
|
520 |
|
|
|a Twenty out-patients with active, chronic duodenal ulcer were treated over a period of 6 weeks with either 0.6 g ranitidine per day or 2 g triletide per day, a new synthetic tripeptide shown to be effective in healing ulcers by increasing the mucosal defence mechanisms. Efficacy was assessed by scoring the intensity of day and night pain before, after 2 and after 6 weeks of treatment, and by endoscopy before and after. Tolerance was assessed by routine laboratory tests, physical examination and a survey of any accessory symptoms. Both drugs significantly relieved pain almost at the same rate and to the same extent, whereas endoscopy showed a not significantly greater improvement in the ranitidine group. It was found, however, that the patients in the triletide group had, on average, a significantly greater intensity of intractable factors on entry than those in the ranitidine group (+75%; p less than 0.02). After stratifying the intractability factor intensity, the 5 patients in the triletide sub-group comparable with those in the ranitidine group exhibited exactly the same behavior on pain relief and a very similar one on endoscopy findings (2 healed, 2 improved and 1 unchanged, compared with 7 healed and 3 improved, respectively). The sub-group with greater severity also showed improvements, both symptomatic and endoscopic, but to a lesser extent, indicating the need for prolonged treatment. Tolerance was good with both drugs. Two patients on triletide reported adverse effects; 1 of increased intensity of previous constipation and the other 1 of mild headache and dizziness, but these could not be related definitely to treatment
|
650 |
|
4 |
|a Clinical Trial
|
650 |
|
4 |
|a Comparative Study
|
650 |
|
4 |
|a Journal Article
|
650 |
|
4 |
|a Randomized Controlled Trial
|
650 |
|
7 |
|a Anti-Ulcer Agents
|2 NLM
|
650 |
|
7 |
|a Oligopeptides
|2 NLM
|
650 |
|
7 |
|a triletide
|2 NLM
|
650 |
|
7 |
|a 50Q6LI773L
|2 NLM
|
650 |
|
7 |
|a Ranitidine
|2 NLM
|
650 |
|
7 |
|a 884KT10YB7
|2 NLM
|
700 |
1 |
|
|a Solmi, L
|e verfasserin
|4 aut
|
773 |
0 |
8 |
|i Enthalten in
|t Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
|d 1995
|g 4(1985), 3 Spec No vom: 15., Seite 182-8
|w (DE-627)NLM023961570
|
773 |
1 |
8 |
|g volume:4
|g year:1985
|g number:3 Spec No
|g day:15
|g pages:182-8
|
912 |
|
|
|a GBV_USEFLAG_A
|
912 |
|
|
|a SYSFLAG_A
|
912 |
|
|
|a GBV_NLM
|
912 |
|
|
|a GBV_ILN_11
|
912 |
|
|
|a GBV_ILN_22
|
912 |
|
|
|a GBV_ILN_24
|
912 |
|
|
|a GBV_ILN_31
|
912 |
|
|
|a GBV_ILN_39
|
912 |
|
|
|a GBV_ILN_40
|
912 |
|
|
|a GBV_ILN_72
|
912 |
|
|
|a GBV_ILN_120
|
912 |
|
|
|a GBV_ILN_121
|
912 |
|
|
|a GBV_ILN_350
|
951 |
|
|
|a AR
|
952 |
|
|
|d 4
|j 1985
|e 3 Spec No
|b 15
|h 182-8
|