Long-term therapy with sustained-release theophylline
Twenty patients with partially reversible bronchial obstruction due to chronic obstructive lung disease participated in a study comparing serum levels, clinical and side-effects of a sustained-release formulation of theophylline with placebo. Prior to the study, theophylline dosages were individuall...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 4(1985), 2 vom: 15., Seite 92-7 |
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| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1985
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Clinical Trial Controlled Clinical Trial Journal Article Delayed-Action Preparations Theophylline C137DTR5RG Albuterol QF8SVZ843E |
| Zusammenfassung: | Twenty patients with partially reversible bronchial obstruction due to chronic obstructive lung disease participated in a study comparing serum levels, clinical and side-effects of a sustained-release formulation of theophylline with placebo. Prior to the study, theophylline dosages were individually adjusted to give serum levels of 55 to 75 mumol/l 4 hours after tablet intake. Theophylline or placebo was then administered every 12 hours with crossover after 6 weeks. During the study, patients were examined in the morning every second week and lung function tests carried out before and after salbutamol inhalation. Doses required to achieve the desired serum concentration showed great inter-individual variations, but the obtained levels were stable during the whole study. Lung function tests were significantly better in the theophylline period. After inhalation of salbutamol, values were also better in the theophylline period but the differences were less marked and of no statistical significance. Subjective improvement from theophylline was not observed. Side-effects reported were mild and caused no withdrawals |
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| Beschreibung: | Date Completed 18.12.1985 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |