A fixed-dose combination of furosemide and spironolactone in digitalized congestive heart failure patients

Twenty-three optimally digitalized patients with congestive heart failure completed a 4-week treatment period with a fixed-drug association of 20 mg furosemide plus 50 mg spironolactone. Eleven patients responded with a 75% decrease in cardiac failure score on a daily dose of 1 capsule of the combin...

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Veröffentlicht in:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 4(1986), 8 vom: 03., Seite 473-9
1. Verfasser: Yasky, J (VerfasserIn)
Weitere Verfasser: Ledesma, G A, Tutera, A, Collia, L F
Format: Aufsatz
Sprache:English
Veröffentlicht: 1986
Zugriff auf das übergeordnete Werk:Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC)
Schlagworte:Journal Article Digitalis Glycosides Drug Combinations lasilacton 124199-68-4 Spironolactone 27O7W4T232 Furosemide 7LXU5N7ZO5
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520 |a Twenty-three optimally digitalized patients with congestive heart failure completed a 4-week treatment period with a fixed-drug association of 20 mg furosemide plus 50 mg spironolactone. Eleven patients responded with a 75% decrease in cardiac failure score on a daily dose of 1 capsule of the combination. The remaining 12 patients were initiated on the same dose, but needed, at the end of the first 14 days, an additional capsule (making a daily total of 40 mg furosemide and 100 mg spironolactone) over the next 2 weeks. On this dose, the patients achieved an average reduction of 52% in their cardiac failure score. There were no treatment failures. Electrolyte abnormalities and side-effects were not observed. The combination product, in a daily dose of 1 or 2 capsules, was found useful and well tolerated in the management of congestive heart failure 
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700 1 |a Tutera, A  |e verfasserin  |4 aut 
700 1 |a Collia, L F  |e verfasserin  |4 aut 
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