The role of haemorheological factors in the ageing brain : long-term therapy with pentoxifylline ('Trental' 400) in elderly patients with initial mental deterioration
Sixty elderly patients suffering from initial mental deterioration (less than 6 months) were divided at random into two groups, homogeneous for age, sex and life habits. For 28 weeks Group I was given a placebo and Group II was given 400 mg pentoxifylline ('Trental' 400) 3-times daily for...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 4(1986), 10 vom: 02., Seite 617-27 |
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| Weitere Verfasser: | , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1986
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Clinical Trial Journal Article Randomized Controlled Trial Theobromine OBD445WZ5P Pentoxifylline SD6QCT3TSU |
| Zusammenfassung: | Sixty elderly patients suffering from initial mental deterioration (less than 6 months) were divided at random into two groups, homogeneous for age, sex and life habits. For 28 weeks Group I was given a placebo and Group II was given 400 mg pentoxifylline ('Trental' 400) 3-times daily for two 3-month periods interrupted by a 4-week wash-out period. Neuropsychological performance and haemorheological parameters were evaluated at the beginning and at the end of each phase of the study. The results showed that pentoxifylline medication significantly improved the psycho-intellectual performance, decreased whole blood viscosity and increased red cell filterability. The results indicate a need to concentrate further study on haemorheological factors in the clinical aspects of the ageing brain, also with a view to allowing for sufficiently long treatment periods |
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| Beschreibung: | Date Completed 29.07.1987 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |