Studies of immunosuppressive substances in human seminal plasma
Endogenous opioids, which have been shown to exhibit pharmacological and physiological activity on the immune system, have recently been reported to inhibit rosette formation between human T lymphocytes and sheep red blood cells. Because those opioids were found at a higher concentration in seminal...
| Veröffentlicht in: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 33(1987), 4 vom: 30. Apr., Seite 551-5 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , |
| Format: | Aufsatz |
| Sprache: | Japanese |
| Veröffentlicht: |
1987
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| Zugriff auf das übergeordnete Werk: | Hinyokika kiyo. Acta urologica Japonica |
| Schlagworte: | English Abstract Journal Article Research Support, Non-U.S. Gov't Endorphins Naloxone 36B82AMQ7N |
| Zusammenfassung: | Endogenous opioids, which have been shown to exhibit pharmacological and physiological activity on the immune system, have recently been reported to inhibit rosette formation between human T lymphocytes and sheep red blood cells. Because those opioids were found at a higher concentration in seminal plasma than in plasma, we studied whether seminal plasma could influence E rosette formation in 23 patients who complained of infertility. Seminal plasma significantly inhibited E rosette formation. With the dilution of seminal plasma, the percentage of E rosette formation increased. The incubation mixture of naloxone prevented the inhibition of E rosette formation produced by seminal plasma. The percentage of E rosette formation was significantly inhibited in azoospermia and oligozoospermia than in normozoospermia. In conclusion, these results suggest that opioids exert a suppressive effect on E rosette formation and may play a role in human spermatogenesis |
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| Beschreibung: | Date Completed 03.09.1987 Date Revised 20.11.2014 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |