Thymus-dependent increase in splenic T cell population in postpartum mice
Cell dynamics in the thymus and spleen of mice during the first allogeneic pregnancy and during postpartum were investigated. A considerable decrease in the number of thymocytes occurred at midpregnancy and was sustained until postpartum. There was an increase in the number of splenic T cells on the...
| Publié dans: | Malignant potential of aneuploid pancreatic endocrine tumours. - 1993. - 10(1986), 4 vom: 15. Apr., Seite 143-50 |
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| Auteur principal: | |
| Autres auteurs: | , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
1986
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| Accès à la collection: | Malignant potential of aneuploid pancreatic endocrine tumours |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Concanavalin A 11028-71-0 |
| Résumé: | Cell dynamics in the thymus and spleen of mice during the first allogeneic pregnancy and during postpartum were investigated. A considerable decrease in the number of thymocytes occurred at midpregnancy and was sustained until postpartum. There was an increase in the number of splenic T cells on the third postpartum day. These splenic T cells were shown to have the Lyt-1+ 2-phenotype, as determined by multiparameter analysis, and their responsiveness to Con A was increased compared with splenic T cells of virgin mice. Since such T cells were not observed in the postpartum spleen of adult thymectomized mice, they may have derived from the thymus. The response to Con A by normal virgin spleen cells was depressed when spleen cells from 3-day postpartum mice were added to the culture as the third party cells. Thus, the increased number of splenic T cells may act as inducer cells in the suppressor circuit during postpartum |
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| Description: | Date Completed 09.06.1986 Date Revised 29.10.2019 published: Print Citation Status MEDLINE |