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231221s1987 xx ||||| 00| ||eng c |
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ober, C
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Prenatal effects of maternal-fetal HLA compatibility
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| 264 |
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1 |
|c 1987
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 18.03.1988
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|a Date Revised 04.04.2017
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Both retrospective studies of idiopathic aborters, as well as prospective studies of normal couples, have shown reduced fertility among couples sharing HLA antigens. However, the effects of maternal-fetal histocompatibility on surviving embryos are largely univestigated. We thus prospectively studied 53 healthy, fertile women whose timed pregnancies were verified within 21 days of conception. Maternal-fetal histocompatibility status was determined for HLA-A,-B, and -DR locus antigens. Fetal growth rates were monitored by ultrasound at 8, 12, and 20 weeks gestation. Neonates were weighed, measured (birthlength, chest circumference, head circumference), and examined within 72 h of delivery (116 major and minor anomalies) in standardized fashion by one of two geneticists. Although no significant differences were found between infants compatible and incompatible at the HLA-A or HLA-B locus, significant differences were observed between HLA-DR compatible and incompatible infants for sex ratios (p less than .003) and minor anomaly rates (p less than .05). Although differences in mean birthweights between HLA-DR compatible and incompatible infants were not significant in this sample, HLA-DR compatible infants were on average 200 grams smaller than HLA-DR incompatible infants. We interpret these findings as evidence for selection against histocompatible fetuses throughout gestation, particularly with respect to HLA-DR compatibility. Potential immunologic and genetic mechanisms are discussed
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a HLA Antigens
|2 NLM
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| 650 |
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7 |
|a HLA-A Antigens
|2 NLM
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| 650 |
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7 |
|a HLA-B Antigens
|2 NLM
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| 650 |
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7 |
|a HLA-DR Antigens
|2 NLM
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| 700 |
1 |
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|a Simpson, J L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ward, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Radvany, R M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andersen, R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elias, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sabbagha, R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t American journal of reproductive immunology and microbiology : AJRIM
|d 1985
|g 15(1987), 4 vom: 01. Dez., Seite 141-9
|w (DE-627)NLM023911689
|x 8755-8920
|7 nnns
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| 773 |
1 |
8 |
|g volume:15
|g year:1987
|g number:4
|g day:01
|g month:12
|g pages:141-9
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