Zona pellucida : current status as a candidate antigen for contraceptive vaccine development
The porcine zona pellucida represents a unique immunocontraceptive target antigen. Initial active immunization studies using crude or partially purified zona components as immunogens resulted in adverse, nonreversible effects on ovarian folliculogenesis, but more recent findings in nonhuman primates...
| Veröffentlicht in: | American journal of reproductive immunology and microbiology : AJRIM. - 1985. - 15(1987), 4 vom: 15. Dez., Seite 122-30 |
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| 1. Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1987
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| Zugriff auf das übergeordnete Werk: | American journal of reproductive immunology and microbiology : AJRIM |
| Schlagworte: | Journal Article Review Antibodies Antigen-antibody Reactions Biology Contraception Contraception Research Contraception, Immunological Examinations And Diagnoses Family Planning mehr... |
| Zusammenfassung: | The porcine zona pellucida represents a unique immunocontraceptive target antigen. Initial active immunization studies using crude or partially purified zona components as immunogens resulted in adverse, nonreversible effects on ovarian folliculogenesis, but more recent findings in nonhuman primates indicate that such effects are not as severe and are reversible. Consequently, current efforts are directed toward identifying a zona immunogen that elicits contraceptive antibodies that produce no adverse effects on the ovary. Other studies are in progress to determine optimal injection/immunization format, proper immunogen dosage, and appropriate adjuvant for use in the zona-antizona immunocontraceptive system. Recent data have been very encouraging and emphasize the contraceptive efficacy of this approach to reproduction control |
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| Beschreibung: | Date Completed 18.03.1988 Date Revised 04.04.2017 published: Print Citation Status MEDLINE |
| ISSN: | 8755-8920 |