|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM031767249 |
| 003 |
DE-627 |
| 005 |
20250126143745.0 |
| 007 |
tu |
| 008 |
231221s1988 xx ||||| 00| ||jpn c |
| 028 |
5 |
2 |
|a pubmed25n0106.xml
|
| 035 |
|
|
|a (DE-627)NLM031767249
|
| 035 |
|
|
|a (NLM)3195414
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a jpn
|
| 100 |
1 |
|
|a Yasumoto, R
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Comparison of enoxacin, ofloxacin, and norfloxacin concentration in human benign prostatic tissue
|
| 264 |
|
1 |
|c 1988
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 12.01.1989
|
| 500 |
|
|
|a Date Revised 21.11.2013
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The penetration of pyridone-carboxylic acid drugs into benign prostatic tissue was examined. Twenty-nine patients were studied; 11 for ofloxacin (OFLX) 10 for enoxacin (ENX); and 8 for norfloxacin (NFLX). These drugs were administered orally at a dose of 200 mg three times one day before and twice on the day of operation. Blood sample was taken 30 min before operation and prostatic tissue sample was taken during operation. The mean prostatic concentration of ENX, OFLX and NFLX was 5.81 +/- 2.95 micrograms/g (range 2.99-7.92), 5.51 +/- 1.79 (3.62-7.19), and 4.42 +/- 1.94 (2.45-7.76), respectively. The mean serum concentration of ENX, OFLX and NFLX was 4.87 +/- 1.39 micrograms/ml (3.13-7.44), 5.36 +/- 1.28 (3.12-8.24), and 2.89 +/- 2.34 (0.87-8.33), respectively. The mean ratio of prostatic concentration/serum concentration of ENX, OFLX and NFLX was 1.21 +/- 0.63 (0.82-3.00), 1.06 +/- 0.31, (0.55-1.54) and 2.06 +/- 1.36 (0.93-4.26), respectively. Our findings suggested that the drugs ENX, OFLX and NFLX are useful for prostatic diseases, especially prostatitis
|
| 650 |
|
4 |
|a Comparative Study
|
| 650 |
|
4 |
|a English Abstract
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a Enoxacin
|2 NLM
|
| 650 |
|
7 |
|a 325OGW249P
|2 NLM
|
| 650 |
|
7 |
|a Ofloxacin
|2 NLM
|
| 650 |
|
7 |
|a A4P49JAZ9H
|2 NLM
|
| 650 |
|
7 |
|a Norfloxacin
|2 NLM
|
| 650 |
|
7 |
|a N0F8P22L1P
|2 NLM
|
| 700 |
1 |
|
|a Asakawa, M
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 34(1988), 8 vom: 08. Aug., Seite 1519-21
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnas
|
| 773 |
1 |
8 |
|g volume:34
|g year:1988
|g number:8
|g day:08
|g month:08
|g pages:1519-21
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_20
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_40
|
| 912 |
|
|
|a GBV_ILN_60
|
| 912 |
|
|
|a GBV_ILN_72
|
| 912 |
|
|
|a GBV_ILN_120
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_2001
|
| 912 |
|
|
|a GBV_ILN_2003
|
| 912 |
|
|
|a GBV_ILN_2005
|
| 912 |
|
|
|a GBV_ILN_2006
|
| 912 |
|
|
|a GBV_ILN_2008
|
| 912 |
|
|
|a GBV_ILN_2010
|
| 912 |
|
|
|a GBV_ILN_2012
|
| 912 |
|
|
|a GBV_ILN_2018
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 34
|j 1988
|e 8
|b 08
|c 08
|h 1519-21
|