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01000naa a22002652 4500 |
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DE-627 |
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20231221115649.0 |
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231221s1988 xx ||||| 00| ||jpn c |
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|a pubmed24n0104.xml
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|a (DE-627)NLM031133509
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|a (NLM)3132029
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a jpn
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| 100 |
1 |
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|a Ohkawa, M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Detection of penicillinase-producing Neisseria gonorrhoeae from male patients with urethritis
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| 264 |
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1 |
|c 1988
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 24.06.1988
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| 500 |
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|a Date Revised 09.12.2020
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Eighty-nine isolates of Neisseria gonorrhoeae from 89 male urethritis patients were studied for beta-lactamases (penicillinase) production, and their susceptibilities to benzylpenicillin, amoxicillin, piperacillin, clavulanic acid/amoxicillin (Augmentin), cephalexin, cefotaxime, spectinomycin and minocycline were determined by an agar plate-dilution method. Penicillinase activity was tested by a chromogenic cephalosporin method with nitrocefin as substrate (CefinaseTM discs, BBL, USA) and by a paper strip acidimetric method with benzylpenicillin as substrate (beta-Lactamase detection papers, Oxoid, UK). In addition, 60 of the 89 patients were examined for Chlamydia trachomatis, using fluorescein-labeled monoclonal antibodies (Direct specimen test; Micro TrakTM, Syva Co., USA). Penicillinase-producing N. gonorrhoeae (PPNG) were found in 12 of the 89 strains (13.5%). Although all these strains of PPNG were highly resistant to benzylpenicillin and amoxicillin, the minimum inhibitory concentrations (MICs) of Augmentin markedly decreased. Piperacillin was highly active against not only non-PPNG but also PPNG strains. More than half the isolates were resistant to cephalexin (MICs greater than or equal to 12.5 micrograms/ml) while all strains including non-PPNG and PPNG were fully sensitive to cefotaxime (MICs less than or equal to 0.20 microgram/ml). Spectinomycin and minocycline had MIC ranges of 6.25 to 25 micrograms/ml and 0.01 to 3.13 micrograms/ml, respectively; the ranges for non-PPNG and PPNG strains were fairly similar. C. trachomatis was detected in 11 (18.3%) out of 60 patients examined. The increasing incidence of PPNG and coexisting chlamydial infection should be taken into account in the treatment of gonococcal urethritis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Penicillinase
|2 NLM
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| 650 |
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7 |
|a EC 3.5.2.-
|2 NLM
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| 700 |
1 |
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|a Nakajima, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tokunaga, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kawaguchi, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sugata, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hisazumi, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ueno, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Watanabe, K
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 34(1988), 1 vom: 01. Jan., Seite 130-6
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
8 |
|g volume:34
|g year:1988
|g number:1
|g day:01
|g month:01
|g pages:130-6
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_20
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| 912 |
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|a GBV_ILN_22
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| 912 |
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|a GBV_ILN_40
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| 912 |
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|a GBV_ILN_60
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| 912 |
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|a GBV_ILN_72
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| 912 |
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|a GBV_ILN_120
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| 912 |
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|a GBV_ILN_350
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| 912 |
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|a GBV_ILN_2001
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| 912 |
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|a GBV_ILN_2003
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| 912 |
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|a GBV_ILN_2005
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| 912 |
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|a GBV_ILN_2006
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| 912 |
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|a GBV_ILN_2008
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| 912 |
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|a GBV_ILN_2010
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| 912 |
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|a GBV_ILN_2012
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| 912 |
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|a GBV_ILN_2018
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| 951 |
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|a AR
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| 952 |
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|d 34
|j 1988
|e 1
|b 01
|c 01
|h 130-6
|