Clinical experience of tegafur-uracil (UFT) against bladder cancer and renal cell carcinoma

The safety of prolonged administration of UFT in which tegafur and uracil were mixed in a ratio of 1:4 in molar fraction was studied in 44 cases of bladder cancer and 10 cases of renal cell carcinoma. Daily doses of UFT were 300-600 mg, and average total doses administered were 102.0 g for bladder c...

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Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 33(1987), 10 vom: 01. Okt., Seite 1728-32
1. Verfasser: Nakagami, Y (VerfasserIn)
Weitere Verfasser: Lin, T T, Ito, H, Hirasawa, S, Tannawa, K, Fujioka, Y, Ogawa, H, Tanaka, K, Yamada, N, Ishii, Y
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1987
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:English Abstract Journal Article Tegafur 1548R74NSZ Uracil 56HH86ZVCT
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520 |a The safety of prolonged administration of UFT in which tegafur and uracil were mixed in a ratio of 1:4 in molar fraction was studied in 44 cases of bladder cancer and 10 cases of renal cell carcinoma. Daily doses of UFT were 300-600 mg, and average total doses administered were 102.0 g for bladder cancer and 116.6 g for renal cell carcinoma cases. Incidence of adverse effects were 25.0% in bladder cancer and 18.5% in renal cell carcinoma cases. Anorexia, nausea, vomiting and decrease in WBC were observed, but rates of having discontinued the administration of UFT were very low, being 9.1% in bladder cancer and 10.0% in renal cell carcinoma. Thus, UFT was considered to be tolerable during prolonged use in bladder cancer and renal cell carcinoma and also a drug in which more usefulness is expected in multidisciplinary treatments in future 
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