Comparison between aerosol and powder delivery system of fenoterol plus ipratropium bromide ('Duovent') in patients with asthma and chronic bronchitis
A study was carried out in 15 stable asthmatics and 5 patients with partially reversible airflow obstruction to compare the efficacy and tolerability of a single dose of 200 micrograms fenoterol plus 80 micrograms ipratropium bromide ('Duovent') administered either by metered dose aerosol...
| Veröffentlicht in: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC). - 1995. - 5(1988), 4 vom: 17., Seite 246-8 |
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| 1. Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1988
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| Zugriff auf das übergeordnete Werk: | Interim guidelines for the control of infections with Vero cytotoxin producing Escherichia coli (VTEC). Subcommittee of the PHLS Working Group on Vero cytotoxin producing Escherichia coli (VTEC) |
| Schlagworte: | Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Aerosols Atropine Derivatives Powders Fenoterol 22M9P70OQ9 Ipratropium |
| Zusammenfassung: | A study was carried out in 15 stable asthmatics and 5 patients with partially reversible airflow obstruction to compare the efficacy and tolerability of a single dose of 200 micrograms fenoterol plus 80 micrograms ipratropium bromide ('Duovent') administered either by metered dose aerosol or as a dry powder preparation for inhalation ('Inhalets'). Using a double-dummy technique, patients received each formulation, in random order, on 2 separate days within 1 week. Spirometric measurements were made over a period of 6 hours after the dose. The results showed that a 35% peak improvement in mean FEV1 occurred with each method of administration and there was no statistical difference between responses. Improvements of 25% were sustained for over 4 hours and effects on pulse rate and tremor were similar for both preparations |
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| Beschreibung: | Date Completed 17.11.1988 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |