Clinical studies on Suncefal (cefpiramide) concentration in prostatic tissue and bladder wall

The cefpiramide (CPM) concentration in prostatic tissue of 19 patients with benign prostatic hypertrophy and bladder wall of 2 patients with bladder tumors was measured, after 2 g of CPM was administered intravenously by bolus technique prior to operation. Prostatic tissue level was 28.4 to 131 micr...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 34(1988), 3 vom: 27. März, Seite 551-4
1. Verfasser: Okishio, N (VerfasserIn)
Weitere Verfasser: Yonezu, M, Hanai, S, Ishiguro, K, Yanaoka, M, Naide, Y
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1988
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:English Abstract Journal Article Cephalosporins cefpiramide P936YA152N
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520 |a The cefpiramide (CPM) concentration in prostatic tissue of 19 patients with benign prostatic hypertrophy and bladder wall of 2 patients with bladder tumors was measured, after 2 g of CPM was administered intravenously by bolus technique prior to operation. Prostatic tissue level was 28.4 to 131 micrograms/g and tissue to serum ratio 0.15 to 0.63 at 12 min. to 220 min. after administration. The T1/2 of CPM in prostatic tissue was 3.29 hours. The bladder wall level was high at both determinations. CPM level in prostatic tissue and bladder wall covered the minimum inhibitory concentration of many bacteria detected from the infected sites. Therefore, CPM which has a strong antimicrobial activity can be considered as a highly useful antibiotic for the treatment of postoperative infections 
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700 1 |a Yanaoka, M  |e verfasserin  |4 aut 
700 1 |a Naide, Y  |e verfasserin  |4 aut 
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