Studies on 5-FU concentration in serum and prostate cancer tissue after oral administration of UFT

The serum, urine and tissue concentrations of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT), 5-fluorouracil (5-FU) and uracil were estimated in 11 patients with prostate cancer (4 cases treated by total prostatectomy and 7 cases by transurethral resection (TUR-P) after oral administration of UFT. The co...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 37(1991), 7 vom: 29. Juli, Seite 711-5
1. Verfasser: Shinoda, I (VerfasserIn)
Weitere Verfasser: Takahashi, Y, Takeuchi, T, Kuriyama, M, Ban, Y, Kawada, Y, Ito, Y, Yamamoto, N, Maeda, S, Tada, K
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1991
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:English Abstract Journal Article Tegafur 1548R74NSZ Uracil 56HH86ZVCT Fluorouracil U3P01618RT
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520 |a The serum, urine and tissue concentrations of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT), 5-fluorouracil (5-FU) and uracil were estimated in 11 patients with prostate cancer (4 cases treated by total prostatectomy and 7 cases by transurethral resection (TUR-P) after oral administration of UFT. The concentration of FT, 5-FU and uracil in the tumor tissue (micrograms/g) were 5.920 +/- 5.902, 0.018 +/- 0.012 (T/S; 2.20) and 7.785 +/- 4.151 in 4 patients treated by total prostatectomy and 1.943 +/- 1.355, 0.024 +/- 0.010 (T/S; 1.46) and 4.616 +/- 2.848 in 7 patients treated by transurethral resection of prostate. The concentrations of FT, 5-FU and uracil in the tumor tissue did not increase as compared with those in normal tissue in 4 cases treated by total prostatectomy 
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700 1 |a Tada, K  |e verfasserin  |4 aut 
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