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240126s2016 xx |||||o 00| ||eng c |
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|a (DE-627)JST140175377
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|a (JST)44014444
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Stark, Zornitza
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Predictive genetic testing for neurodegenerative conditions: how should conflicting interests within families be managed?
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
|b c
|2 rdamedia
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|a Online-Ressource
|b cr
|2 rdacarrier
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|a Predictive genetic testing for a neurodegenerative condition in one individual in a family may have implications for other family members, in that it can reveal their genetic status. Herein a complex clinical case is explored where the testing wish of one family member was in direct conflict to that of another. The son of a person at 50% risk of an autosomal dominant neurodegenerative condition requested testing to reveal his genetic status. The main reason for the request was if he had the familial mutation, he and his partner planned to utilise preimplantation genetic diagnosis to prevent his offspring having the condition. His at-risk parent was clear that if they found out they had the mutation, they would commit suicide. We assess the potential benefits and harms from acceding to or denying such a request and present an approach to balancing competing rights of individuals within families at risk of late-onset genetic conditions, where family members have irreconcilable differences with respect to predictive testing. We argue that while it may not be possible to completely avoid harm in these situations, it is important to consider the magnitude of risks, and make every effort to limit the potential for adverse outcomes.
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|a © 2016 BMJ Publishing Group Ltd and the Institute of Medical Ethics
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| 650 |
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4 |
|a Behavioral sciences
|x Sociology
|x Human societies
|x Social institutions
|x Families
|x Family members
|x Parents
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Medical genetics
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Population genetics
|x Genetic variation
|x Genetic mutation
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| 650 |
|
4 |
|a Behavioral sciences
|x Sociology
|x Human societies
|x Social institutions
|x Families
|x Family members
|x Sons
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| 650 |
|
4 |
|a Behavioral sciences
|x Sociology
|x Human societies
|x Social institutions
|x Families
|x Family members
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| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Genetic diseases
|x Nervous system heredodegenerative disorders
|x Huntington disease
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Developmental biology
|x Embryology
|x Embryos
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Genetics
|x Genetic inheritance
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| 650 |
|
4 |
|a Social sciences
|x Population studies
|x Human populations
|x At risk population
|x Youths at risk
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Genetics
|x Medical genetics
|x Genetic services
|x Genetic screening
|x Clinical ethics
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| 655 |
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4 |
|a research-article
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| 700 |
1 |
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|a Wallace, Jane
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gillam, Lynn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Burgess, Matthew
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Delatycki, Martin B
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of Medical Ethics. in
|d Society for the Study of Medical Ethics
|g 42(2016), 10, Seite 640-642
|w (DE-627)JST049950649
|x 14734257
|7 nnns
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| 773 |
1 |
8 |
|g volume:42
|g year:2016
|g number:10
|g pages:640-642
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| 856 |
4 |
0 |
|u http://www.jstor.org/stable/44014444
|3 Volltext
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|a GBV_USEFLAG_A
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|a GBV_JST
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|a AR
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|d 42
|j 2016
|e 10
|h 640-642
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