Epilepsy, excess deaths and years of life lost from external causes

Epilepsy, excess deaths and years of life lost from external causes

We systematically quantified excess mortality in epilepsy patients by cause of death using the populationattributable fraction and epilepsy-attributable years of potential life lost (YPLL) by age 75 years at ages 15 and over. We updated and undertook a re-review of mortality studies from our previou...

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Veröffentlicht in:European Journal of Epidemiology. - Springer Science + Business Media. - 31(2016), 5, Seite 445-453
1. Verfasser: Nevalainen, Olli (VerfasserIn)
Weitere Verfasser: Simola, Mikko, Ansakorpi, Hanna, Raitanen, Jani, Artama, Miia, Isojärvi, Jouko, Auvinen, Anssi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:European Journal of Epidemiology
Schlagworte:Health sciences Social sciences Biological sciences Behavioral sciences Philosophy
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520 |a We systematically quantified excess mortality in epilepsy patients by cause of death using the populationattributable fraction and epilepsy-attributable years of potential life lost (YPLL) by age 75 years at ages 15 and over. We updated and undertook a re-review of mortality studies from our previous systematic review following PRISMA guidelines to identify cohort studies of general epilepsy populations reporting a relative risk (RR) of death by cause relative to the background rates in the population. Studies on epilepsy prevalence were identified through published reviews. Country-specific mortality figures were obtained from the WHO World Mortality Database. We performed a pooled analysis with the DerSimonian-Laird random effects method. In countries with very high Human Development Indices, epilepsy contributed to 0.5-1.1 % of all deaths in the total population. Among external causes, suicides (RR 2.9, 95 % confidence interval 2.2-3.8; I² 52 %) were the major contributor to YPLL, corresponding to 6.7 % and 4.2 % of excess YPLL due to epilepsy in the United States (US) and in the United Kingdom (UK) in 2010, with 541 (346-792) and 44 (28-65) excess suicide cases, respectively. Fatal accidental falls were more common, with 813 (610-1064) and 95 (71-125) excess deaths in the US and in the UK, but these caused only 2.0 % of excess YPLL as they occurred in older age groups. Suicides were the most important external cause of death in epilepsy patients in terms of excess YPLL, whereas other external causes were either more common in older ages or caused less excess deaths. 
540 |a © Springer Science+Business Media 2016 
650 4 |a Health sciences  |x Medical conditions  |x Diseases  |x Nervous system diseases  |x Central nervous system diseases  |x Neurological disorders  |x Brain disorders  |x Epilepsy 
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700 1 |a Artama, Miia  |e verfasserin  |4 aut 
700 1 |a Isojärvi, Jouko  |e verfasserin  |4 aut 
700 1 |a Auvinen, Anssi  |e verfasserin  |4 aut 
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