Structural studies of viperin, an antiviral radical SAM enzyme
Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication. We determined crystal structures of an anaerobically prepared fragment of mouse viperin (residues 45–362) complexed with S-adenosylhomocysteine (SAH) or 5′-deoxyadenosine (5′-dAdo) and L-methionine...
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Détails bibliographiques
| Publié dans: | Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences. - 114(2017), 26, Seite 6806-6811
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| Auteur principal: |
Fenwick, Michael K.
(Auteur) |
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| Autres auteurs: |
Li, Yue,
Cresswell, Peter,
Modis, Yorgo,
Ealick, Steven E. |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2017
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| Accès à la collection: | Proceedings of the National Academy of Sciences of the United States of America
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| Sujets: | radical SAM
IFN-stimulated gene
antiviral cellular factor
free radical
S-adenosyl methionine |
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