A dose finding design for seizure reduction in neonates
Clinical trials in vulnerable populations are extremely difficult to conduct. A sequential phase I–II trial aimed at finding the appropriate dose of levetiracetam for treating neonatal seizures was planned with a maximum sample size of 50 newborns. Three primary outcomes are considered: efficacy and...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Journal of the Royal Statistical Society. Series C (Applied Statistics). - Blackwell Publishers. - 68(2019), 2, Seite 427-444
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| 1. Verfasser: |
Ursino, Moreno
(VerfasserIn) |
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| Weitere Verfasser: |
Yuan, Ying,
Alberti, Corinne,
Comets, Emmanuelle,
Favrais, Geraldine,
Friede, Tim,
Lentz, Frederike,
Stallard, Nigel,
Zohar, Sarah |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Journal of the Royal Statistical Society. Series C (Applied Statistics)
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