Risk factors for influenza-related complications in children during the 2009/10 pandemic a UK primary care cohort study using linked routinely collected data

Risk factors for influenza-related complications in children during the 2009/10 pandemic : a UK primary care cohort study using linked routinely collected data

Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using routinely col...

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Bibliographische Detailangaben
Veröffentlicht in:Epidemiology and Infection. - Cambridge University Press, 1987. - 146(2018), 7, Seite 817-823
1. Verfasser: Lee, J. J. (VerfasserIn)
Weitere Verfasser: Bankhead, C., Smith, M., Kousoulis, A. A., Butler, C. C., Wang, K.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Epidemiology and Infection
Schlagworte:Children influenza primary care risk factors
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520 |a Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using routinely collected linked data from the Clinical Practice Research Datalink on children aged 17 years and younger who presented with influenza/ILI during the 2009/10 pandemic. We calculated odds ratios (ORs) for potential risk factors in relation to influenza-related complications, complications requiring intervention, pneumonia, all-cause hospitalisation and hospitalisation due to influenza-related complications within 30 days of presentation. Analyses were adjusted for potential confounders including age, vaccination and socio-economic deprivation. Asthma was a risk factor for influenza-related complications (adjusted OR 1.48, 95% confidence interval (CI) 1.21–1.80, < 0.001), complications requiring intervention (adjusted OR 1.44, 95% CI 1.11–1.88; = 0.007), pneumonia (adjusted OR 1.64, 95% CI 1.07–2.51, = 0.024) and hospitalisation due to influenza-related complications (adjusted OR 2.46, 95% CI 1.09–5.56, = 0.031). Neurological conditions were risk factors for all-cause hospitalisation (adjusted OR 4.25, 95% CI 1.50–12.07, = 0.007) but not influenza-related complications (adjusted OR 1.46, 95% CI 0.83–2.56, = 0.189). Community-based early interventions to prevent influenza-related clinical deterioration should therefore be primarily targeted at children with asthma and neurological conditions. 
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700 1 |a Smith, M.  |e verfasserin  |4 aut 
700 1 |a Kousoulis, A. A.  |e verfasserin  |4 aut 
700 1 |a Butler, C. C.  |e verfasserin  |4 aut 
700 1 |a Wang, K.  |e verfasserin  |4 aut 
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