Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
Whereas all mammals have one glutamate dehydrogenase gene (GLUD1), humans and apes carry an additional gene (GLUD2), which encodes an enzyme with distinct biochemical properties. We inserted a bacterial artificial chromosome containing the human GLUD2 gene into mice and analyzed the resulting change...
Ausführliche Beschreibung
Bibliographische Detailangaben
| 1. Verfasser: |
Li, Qian
(VerfasserIn) |
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| Weitere Verfasser: |
Guo, Song,
Jiang, Xi,
Bryk, Jaroslaw,
Naumann, Ronald,
Enard, Wolfgang,
Tomita, Masaru,
Sugimoto, Masahiro,
Khaitovich, Philipp,
Pääbo, Svante |
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| Format: | Online-Aufsatz
|
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| Sprache: | English |
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| Veröffentlicht: |
2016
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| Schlagworte: | human evolution
GLUD2
brain metabolism |
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