Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome

The Li-Fraumeni syndrome (LFS) and its variant form (LFL) is a familial predisposition to multiple forms of childhood, adolescent, and adult cancers associated with germ-line mutation in the TP53 tumor suppressor gene....

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Veröffentlicht in:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 111(2014), 43, Seite 15497-15501
1. Verfasser: Ariffin, Hany (VerfasserIn)
Weitere Verfasser: Hainaut, Pierre, Puzio-Kuter, Anna, Choong, Soo Sin, Chan, Adelyne Sue Li, Tolkunov, Denis, Rajagopal, Gunaretnam, Kang, Wenfeng, Lim, Leon Li Wen, Krishnan, Shekhar, Chen, Kok-Siong, Achatz, Maria Isabel, Karsa, Mawar, Shamsani, Jannah, Levine, Arnold J., Chan, Chang S.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Proceedings of the National Academy of Sciences of the United States of America
Schlagworte:Biological sciences Health sciences Applied sciences Behavioral sciences