Occupational exposure and ovarian cancer risk

Occupational exposure and ovarian cancer risk

Purpose: Relatively little work has been done concerning occupational risk factors in ovarian cancer. Although studies conducted in occupational settings have reported positive associations, their usefulness is generally limited by the lack of information on important confounders. In a population-ba...

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Veröffentlicht in:Cancer Causes & Control. - Springer Science + Business Media. - 25(2014), 7, Seite 829-841
1. Verfasser: Le, Nhu D. (VerfasserIn)
Weitere Verfasser: Leung, Andy, Brooks-Wilson, Angela, Gallagher, Richard P., Swenerton, Kenneth D., Demers, Paul A., Cook, Linda S.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Cancer Causes & Control
Schlagworte:Health sciences Economics Applied sciences Behavioral sciences Business Social sciences
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520 |a Purpose: Relatively little work has been done concerning occupational risk factors in ovarian cancer. Although studies conducted in occupational settings have reported positive associations, their usefulness is generally limited by the lack of information on important confounders. In a population-based case–control study, we assessed risk for developing epithelial ovarian cancer (EOC) associated with occupational exposure while accounting for important confounders. Methods: Participants were identified through provincial population-based registries. Lifetime occupational history and information on potential confounding factors were obtained through a self-administered questionnaire. Unconditional logistic regression and the likelihood ratio test were used to assess EOC risk with each occupation (or industry), relative to all other occupations (or industries), adjusting for potential confounders including body mass index, oral contraceptive use, menopausal hormone therapy, parity, age at first childbirth, age at menarche, age at menopause, family history of breast and ovarian cancer in mother and sister(s), tubal ligation, partial oophorectomy, and hysterectomy. Occupations and industries were coded according to the Canadian Standard Occupational Classification (SOC) and Standard Industrial Classification (SIC). Results: Significant excess risk was observed for several groups of teaching occupations, including SOC 27, teaching and related (adjusted OR 1.77,95 % CI 1.15–2.81) and SOC 279, other teaching and related (adjusted OR 3.11, 95 % CI 1.35–8.49). Significant excess was also seen for a four-digit occupational group SOC 4131, bookkeepers and accounting clerks (adjusted OR 2.80, 95 % CI 1.30–6.80). Industrial sub-groups showing significant excess risk included SIC 65, other retail stores (adjusted OR 2.19, 95 % CI 1.16–4.38); SIC 85, educational service (adjusted OR 1.45, 95 % CI 1.00–2.13); and SIC 863, non-institutional health services (adjusted OR 2.54, 95 % CI 1.13–6.52). Conclusions: Our study found an elevated EOC risk for teaching occupations and is the first study to observe such an increased risk after adjustment for potential confounders. Further studies with more detailed assessment of the work environment and unique lifestyle characteristics may be fruitful in elucidating this etiology. 
650 4 |a Health sciences  |x Medical conditions  |x Diseases  |x Neoplasia  |x Cancer  |x Ovarian cancer 
650 4 |a Economics  |x Economic disciplines  |x Labor economics  |x Employment  |x Occupations 
650 4 |a Economics  |x Economic disciplines  |x Financial economics  |x Finance  |x Financial management  |x Financial risk 
650 4 |a Applied sciences  |x Engineering  |x Industrial engineering 
650 4 |a Behavioral sciences  |x Sociology  |x Human societies  |x Social institutions  |x Families  |x Family background  |x Family history 
650 4 |a Business  |x Industry  |x Industrial sectors  |x Service industries  |x Building services  |x Custodial services 
650 4 |a Economics  |x Economic disciplines  |x Economic geography  |x Real estate  |x Real property  |x Industrial real estate 
650 4 |a Social sciences  |x Population studies  |x Mortality 
650 4 |a Business  |x Industry  |x Industrial safety 
650 4 |a Business  |x Industry 
655 4 |a research-article 
700 1 |a Leung, Andy  |e verfasserin  |4 aut 
700 1 |a Brooks-Wilson, Angela  |e verfasserin  |4 aut 
700 1 |a Gallagher, Richard P.  |e verfasserin  |4 aut 
700 1 |a Swenerton, Kenneth D.  |e verfasserin  |4 aut 
700 1 |a Demers, Paul A.  |e verfasserin  |4 aut 
700 1 |a Cook, Linda S.  |e verfasserin  |4 aut 
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