Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

β-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating neurodegenerative diseases on the island of Guam in the Pacific Ocean. Because cyanobacteria are widespread globally, we hypothesized that BMA...

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Publié dans:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences. - 107(2010), 20, Seite 9252-9257
Auteur principal: Jonasson, Sara (Auteur)
Autres auteurs: Eriksson, Johan, Berntzon, Lotta, Spáčil, Zdeněk, llag, Leopold L., Ronnevi, Lars-Olof, Rasmussen, Ulla, Bergman, Birgitta, Karl, David
Format: Article en ligne
Langue:English
Publié: 2010
Accès à la collection:Proceedings of the National Academy of Sciences of the United States of America
Sujets:Biological sciences Physical sciences Health sciences
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245 1 0 |a Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure 
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520 |a β-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating neurodegenerative diseases on the island of Guam in the Pacific Ocean. Because cyanobacteria are widespread globally, we hypothesized that BMAA might occur and bioaccumulate in other ecosystems. Here we demonstrate, based on a recently developed extraction and HPLC-MS/MS method and long-term monitoring of BMAA in cyanobacterial populations of a temperate aquatic ecosystem (Baltic Sea, 2007—2008), that BMAA is biosynthesized by cyanobacterial genera dominating the massive surface blooms of this water body. BMAA also was found at higher concentrations in organisms of higher trophic levels that directly or indirectly feed on cyanobacteria, such as zooplankton and various vertebrates (fish) and invertebrates (mussels, oysters). Pelagic and benthic fish species used for human consumption were included. The highest BMAA levels were detected in the muscle and brain of bottom-dwelling fishes. The discovery of regular biosynthesis of the neurotoxin BMAA in a large temperate aquatic eco-system combined with its possible transfer and bioaccumulation within major food webs, some ending in human consumption, is alarming and requires attention. 
650 4 |a Biological sciences  |x Biology  |x Botany  |x Marine botany  |x Phycology  |x Algae  |x Cyanobacteria 
650 4 |a Biological sciences  |x Biology  |x Marine biology  |x Aquatic organisms  |x Plankton  |x Zooplankton 
650 4 |a Biological sciences  |x Biochemistry  |x Biomolecules  |x Toxins  |x Neurotoxins 
650 4 |a Biological sciences  |x Ecology  |x Ecosystems  |x Aquatic ecosystems  |x Marine ecosystems 
650 4 |a Physical sciences  |x Earth sciences  |x Geography  |x Geomorphology  |x Bodies of water  |x Seas 
650 4 |a Biological sciences  |x Biology  |x Zoology  |x Animals  |x Fish  |x Marine fishes 
650 4 |a Biological sciences  |x Biology  |x Zoology  |x Animals  |x Mollusks  |x Mussels 
650 4 |a Health sciences  |x Medical conditions  |x Diseases  |x Nervous system diseases  |x Neurodegenerative diseases  |x Motor neuron disease  |x Amyotrophic lateral sclerosis 
650 4 |a Biological sciences  |x Ecology  |x Ecosystems  |x Terrestrial ecosystems 
650 4 |a Biological sciences  |x Biochemistry  |x Biomolecules  |x Toxins 
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700 1 |a Eriksson, Johan  |e verfasserin  |4 aut 
700 1 |a Berntzon, Lotta  |e verfasserin  |4 aut 
700 1 |a Spáčil, Zdeněk  |e verfasserin  |4 aut 
700 1 |a llag, Leopold L.  |e verfasserin  |4 aut 
700 1 |a Ronnevi, Lars-Olof  |e verfasserin  |4 aut 
700 1 |a Rasmussen, Ulla  |e verfasserin  |4 aut 
700 1 |a Bergman, Birgitta  |e verfasserin  |4 aut 
700 1 |a Karl, David  |e verfasserin  |4 aut 
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