Sequence Context Effect for hMSH2-hMSH6 Mismatch-Dependent Activation
Numerous DNA mismatches and lesions activate MutS homologue (MSH) ATPase activity that is essential for mismatch repair (MMR). We have found that a mismatch embedded in a nearest-neighbor sequence context containing symmetric 3′-purines (2 × 3′-purines) enhanced, whereas symmetric 3′-pyrimidines (2...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 106(2009), 11, Seite 4177-4182
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| 1. Verfasser: |
Mazurek, Anthony
(VerfasserIn) |
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| Weitere Verfasser: |
Johnson, Christopher N.,
Germann, Markus W.,
Fishel, Richard,
Kolodner, Richard D. |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Proceedings of the National Academy of Sciences of the United States of America
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| Schlagworte: | ATPase
hereditary nonpolyposis colon cancer
human
mismatch repair
MutS homologs
Physical sciences
Biological sciences
Health sciences |
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