Expression, Regulation, and Chromosomal Localization of the Max Gene

Expression, Regulation, and Chromosomal Localization of the Max Gene

The Max gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA binding site of Myc. Here we examine the expression of Max RNA in comparison to Myc RNA during cell growth and differentiation. Two species of RNA, a...

Description complète

Détails bibliographiques
Publié dans:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences. - 89(1992), 7, Seite 3111-3115
Auteur principal: Wagner, Andrew J. (Auteur)
Autres auteurs: Le Beau, Michelle M., Diaz, Manuel O., Hay, Nissim
Format: Article en ligne
Langue:English
Publié: 1992
Accès à la collection:Proceedings of the National Academy of Sciences of the United States of America
Sujets:Genetics Myc Cell Growth Differentiation Protooncogene Transformation Physical sciences Biological sciences
LEADER 01000caa a22002652c 4500
001 JST069658315
003 DE-627
005 20240622185936.0
007 cr uuu---uuuuu
008 150325s1992 xx |||||o 00| ||eng c
035 |a (DE-627)JST069658315 
035 |a (JST)2359044 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Wagner, Andrew J.  |e verfasserin  |4 aut 
245 1 0 |a Expression, Regulation, and Chromosomal Localization of the Max Gene 
264 1 |c 1992 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
520 |a The Max gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA binding site of Myc. Here we examine the expression of Max RNA in comparison to Myc RNA during cell growth and differentiation. Two species of RNA, a major 2.0- and a minor 1.7-kilobase species, hybridized specifically to a Max cDNA probe in all human and murine cell lines that were tested. Unlike Myc, the steady-state level of Max RNA is not significantly modulated with respect to proliferation or differentiation. Max RNA is expressed in quiescent BALB/c3T3 cells and is modestly increased 3 h after addition of serum to the quiescent cells. In contrast to Myc RNA, Max RNA does not decline immediately upon induction of differentiation of HL60 cells by dimethyl sulfoxide, and only a modest decrease of Max RNA was observed 72 h after induction of differentiation. Unlike Myc RNA, Max RNA is relatively stable with a half-life of >3 h and, therefore, does not exhibit the characteristic short half-life of RNAs encoded by most immediate early genes. The human Max gene was localized to chromosome 14, band q23. With respect to the recurring abnormalities in human tumors, this region of chromosome 14 is involved in deletions in B-cell chronic lymphocytic leukemia and malignant lymphomas and in the 12;14 translocation in uterine leiomyomas. 
540 |a Copyright 1992 The National Academy of Sciences of the United States of America 
650 4 |a Genetics 
650 4 |a Myc 
650 4 |a Cell Growth 
650 4 |a Differentiation 
650 4 |a Protooncogene 
650 4 |a Transformation 
650 4 |a Physical sciences  |x Chemistry  |x Chemical compounds  |x Chemicals  |x Acids  |x Nucleic acids  |x RNA 
650 4 |a Biological sciences  |x Biology  |x Cytology  |x Cell biology  |x Cells  |x Cultured cells  |x Cell lines 
650 4 |a Biological sciences  |x Biology  |x Cytology  |x Cell biology  |x Cells  |x Cultured cells  |x Cell lines  |x 3T3 cells 
650 4 |a Physical sciences  |x Chemistry  |x Chemical compounds  |x Chemicals  |x Acids  |x Nucleic acids  |x DNA  |x Single stranded DNA  |x Complementary DNA 
650 4 |a Biological sciences  |x Biology  |x Developmental biology  |x Embryology  |x Cellular differentiation 
650 4 |a Biological sciences  |x Biology  |x Cytology  |x Cell biology  |x Cell physiology  |x Cell growth 
650 4 |a Biological sciences  |x Biology  |x Cytology  |x Cell biology  |x Cells  |x Cultured cells  |x Cell lines  |x 3T3 cells  |x BALB 3T3 cells 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Molecular genetics  |x Gene expression  |x Gene expression regulation 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Molecular genetics  |x Genes 
650 4 |a Biological sciences  |x Biology  |x Physiology  |x Body composition  |x Body fluids  |x Blood  |x Blood cells  |x Leukocytes  |x Mononuclear leukocytes  |x Lymphocytes  |x B lymphocytes 
655 4 |a research-article 
700 1 |a Le Beau, Michelle M.  |e verfasserin  |4 aut 
700 1 |a Diaz, Manuel O.  |e verfasserin  |4 aut 
700 1 |a Hay, Nissim  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Proceedings of the National Academy of Sciences of the United States of America  |d National Academy of Sciences  |g 89(1992), 7, Seite 3111-3115  |w (DE-627)254235379  |w (DE-600)1461794-8  |x 10916490  |7 nnas 
773 1 8 |g volume:89  |g year:1992  |g number:7  |g pages:3111-3115 
856 4 0 |u https://www.jstor.org/stable/2359044  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_JST 
912 |a GBV_ILN_11 
912 |a GBV_ILN_20 
912 |a GBV_ILN_22 
912 |a GBV_ILN_23 
912 |a GBV_ILN_24 
912 |a GBV_ILN_31 
912 |a GBV_ILN_39 
912 |a GBV_ILN_40 
912 |a GBV_ILN_60 
912 |a GBV_ILN_62 
912 |a GBV_ILN_63 
912 |a GBV_ILN_65 
912 |a GBV_ILN_69 
912 |a GBV_ILN_70 
912 |a GBV_ILN_72 
912 |a GBV_ILN_73 
912 |a GBV_ILN_74 
912 |a GBV_ILN_90 
912 |a GBV_ILN_95 
912 |a GBV_ILN_100 
912 |a GBV_ILN_105 
912 |a GBV_ILN_110 
912 |a GBV_ILN_120 
912 |a GBV_ILN_151 
912 |a GBV_ILN_161 
912 |a GBV_ILN_168 
912 |a GBV_ILN_170 
912 |a GBV_ILN_171 
912 |a GBV_ILN_213 
912 |a GBV_ILN_230 
912 |a GBV_ILN_252 
912 |a GBV_ILN_285 
912 |a GBV_ILN_293 
912 |a GBV_ILN_370 
912 |a GBV_ILN_374 
912 |a GBV_ILN_381 
912 |a GBV_ILN_602 
912 |a GBV_ILN_702 
912 |a GBV_ILN_2001 
912 |a GBV_ILN_2003 
912 |a GBV_ILN_2005 
912 |a GBV_ILN_2006 
912 |a GBV_ILN_2007 
912 |a GBV_ILN_2009 
912 |a GBV_ILN_2010 
912 |a GBV_ILN_2011 
912 |a GBV_ILN_2014 
912 |a GBV_ILN_2015 
912 |a GBV_ILN_2018 
912 |a GBV_ILN_2020 
912 |a GBV_ILN_2021 
912 |a GBV_ILN_2026 
912 |a GBV_ILN_2044 
912 |a GBV_ILN_2050 
912 |a GBV_ILN_2088 
912 |a GBV_ILN_2107 
912 |a GBV_ILN_2110 
912 |a GBV_ILN_2190 
912 |a GBV_ILN_2360 
912 |a GBV_ILN_2943 
912 |a GBV_ILN_2946 
912 |a GBV_ILN_2949 
912 |a GBV_ILN_2951 
912 |a GBV_ILN_4012 
912 |a GBV_ILN_4027 
912 |a GBV_ILN_4028 
912 |a GBV_ILN_4029 
912 |a GBV_ILN_4035 
912 |a GBV_ILN_4037 
912 |a GBV_ILN_4046 
912 |a GBV_ILN_4112 
912 |a GBV_ILN_4116 
912 |a GBV_ILN_4125 
912 |a GBV_ILN_4126 
912 |a GBV_ILN_4242 
912 |a GBV_ILN_4249 
912 |a GBV_ILN_4266 
912 |a GBV_ILN_4305 
912 |a GBV_ILN_4306 
912 |a GBV_ILN_4307 
912 |a GBV_ILN_4309 
912 |a GBV_ILN_4310 
912 |a GBV_ILN_4311 
912 |a GBV_ILN_4313 
912 |a GBV_ILN_4314 
912 |a GBV_ILN_4316 
912 |a GBV_ILN_4317 
912 |a GBV_ILN_4319 
912 |a GBV_ILN_4322 
912 |a GBV_ILN_4323 
912 |a GBV_ILN_4324 
912 |a GBV_ILN_4325 
912 |a GBV_ILN_4335 
912 |a GBV_ILN_4338 
912 |a GBV_ILN_4346 
912 |a GBV_ILN_4367 
912 |a GBV_ILN_4393 
912 |a GBV_ILN_4700 
951 |a AR 
952 |d 89  |j 1992  |e 7  |h 3111-3115