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|a (DE-627)JST045799083
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|a (JST)27594185
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Wathen, J. Kyle
|e verfasserin
|4 aut
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|a Implementation of Backward Induction for Sequentially Adaptive Clinical Trials
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
|b c
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|a Online-Ressource
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|a In many clinical trials, patients are enrolled and data are collected sequentially, with interim decisions, including what treatment the next patient should receive and whether or not the trial should be terminated or continued, being based on the accruing data. This naturally leads to application of Bayesian sequential procedures for trial monitoring. This article discusses the implementation and computational tasks involved in the use of backward induction for making decisions during a clinical trial. An efficient method is presented for storing and retrieving decision tables that represent the decision trees characterizing all possible decisions made when implementing a clinical trial using backward induction. We address the general computational needs, and illustrate the ideas with a specific example of a two-arm trial with a binary outcome and a maximum sample size of 200 patients.
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|a Copyright 2006 American Statistical Association, the Institute of Mathematical Statistics, and the Interface Foundation of North America
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|a Bayesian sequential analysis
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|a Decision theory
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|a Dynamic programming
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|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
|x Decision analysis
|x Decision trees
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|a Economics
|x Microeconomics
|x Economic utility
|x Expected utility
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|a Health sciences
|x Medical sciences
|x Medical research
|x Clinical research
|x Clinical trials
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|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
|x Backward induction
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|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Descriptive statistics
|x Statistical sampling
|x Random allocation
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4 |
|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
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4 |
|a Philosophy
|x Applied philosophy
|x Philosophy of science
|x Scientific method
|x Experimentation
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650 |
|
4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Descriptive statistics
|x Measures of variability
|x Sample size
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650 |
|
4 |
|a Applied sciences
|x Research methods
|x Survey research
|x Survey responses
|x Response rates
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650 |
|
4 |
|a Information science
|x Data products
|x Datasets
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650 |
|
4 |
|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
|x Decision analysis
|x Decision trees
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650 |
|
4 |
|a Economics
|x Microeconomics
|x Economic utility
|x Expected utility
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650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Medical research
|x Clinical research
|x Clinical trials
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650 |
|
4 |
|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
|x Backward induction
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650 |
|
4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Descriptive statistics
|x Statistical sampling
|x Random allocation
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650 |
|
4 |
|a Behavioral sciences
|x Psychology
|x Cognitive psychology
|x Cognitive processes
|x Decision making
|
650 |
|
4 |
|a Philosophy
|x Applied philosophy
|x Philosophy of science
|x Scientific method
|x Experimentation
|
650 |
|
4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Descriptive statistics
|x Measures of variability
|x Sample size
|
650 |
|
4 |
|a Applied sciences
|x Research methods
|x Survey research
|x Survey responses
|x Response rates
|
650 |
|
4 |
|a Information science
|x Data products
|x Datasets
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655 |
|
4 |
|a research-article
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1 |
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|a Christen, J. Andrés
|e verfasserin
|4 aut
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0 |
8 |
|i Enthalten in
|t Journal of Computational and Graphical Statistics
|d American Statistical Association, Institute of Mathematical Statistics, and Interface Foundation of North America, 1992
|g 15(2006), 2, Seite 398-413
|w (DE-627)320519414
|w (DE-600)2014382-5
|x 15372715
|7 nnns
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|g volume:15
|g year:2006
|g number:2
|g pages:398-413
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|u https://www.jstor.org/stable/27594185
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|d 15
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|h 398-413
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