Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes
In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by the continuous transition from stem cells to transient amplifying cells. We now report that downregulation of 1...
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Bibliographische Detailangaben
| Veröffentlicht in: | The Journal of Cell Biology. - Rockefeller University Press, 1962. - 149(2000), 5, Seite 1117-1129
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| 1. Verfasser: |
Dellambra, Elena
(VerfasserIn) |
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| Weitere Verfasser: |
Golisano, Osvaldo,
Bondanza, Sergio,
Siviero, Emanuela,
Lacal, Pedro,
Molinari, Marta,
D'Atri, Stefania,
de Luca, Michele |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2000
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| Zugriff auf das übergeordnete Werk: | The Journal of Cell Biology
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| Schlagworte: | Telomerase
Stem cells
Transformation
Senescence
Immortalization
p16 INK4 a
Biological sciences |
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