The Influence of Design Characteristics on Statistical Inference in Nonlinear Estimation: A Simulation Study Based on Survival Data and Hazard Modeling

This paper describes the influence of design characteristics on the statistical inference for an ecotoxicological hazard-based model using simulated survival data. The design characteristics of interest are the number and spacing of observations (counts) in time, the number and spacing of exposure c...

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Veröffentlicht in:Journal of Agricultural, Biological, and Environmental Statistics. - Springer Science + Business Media. - 5(2000), 3, Seite 323-341
1. Verfasser: Andersen, J. S. (VerfasserIn)
Weitere Verfasser: Bedaux, J. J. M., Holst, H.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2000
Zugriff auf das übergeordnete Werk:Journal of Agricultural, Biological, and Environmental Statistics
Schlagworte:Large-sample theory No-effect concentration Profile likelihood Small samples Physical sciences Social sciences Mathematics Environmental studies Philosophy Applied sciences Information science
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520 |a This paper describes the influence of design characteristics on the statistical inference for an ecotoxicological hazard-based model using simulated survival data. The design characteristics of interest are the number and spacing of observations (counts) in time, the number and spacing of exposure concentrations (within cmin and cmax), and the initial number of individuals at time 0 in each concentration. A comparison of the coverage probabilities for confidence limits arising from the profile-likelihood approach and the Wald-based approach is carried out. The Wald-based approach is very sensitive to the choice of design characteristics, whereas the profile-likelihood approach is more robust and unbiased. Special attention is paid to estimating a parametric no-effect concentration in realistic small-sample situations since this is the most interesting parameter from an environmental protection point of view. 
540 |a Copyright 2000 American Statistical Association and the International Biometric Society 
650 4 |a Large-sample theory 
650 4 |a No-effect concentration 
650 4 |a Profile likelihood 
650 4 |a Small samples 
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650 4 |a Mathematics  |x Applied mathematics  |x Statistics  |x Applied statistics  |x Statistical results  |x Statistical properties  |x Estimate reliability  |x Confidence interval  |x Confidence limits 
650 4 |a Mathematics  |x Applied mathematics  |x Statistics  |x Applied statistics  |x Inferential statistics  |x Statistical inferences 
650 4 |a Environmental studies  |x Environmental sciences  |x Environmental toxicology  |x Ecotoxicology 
650 4 |a Philosophy  |x Applied philosophy  |x Philosophy of science  |x Scientific method  |x Experimentation  |x Experiment design 
650 4 |a Mathematics  |x Mathematical values  |x Mathematical variables  |x Mathematical independent variables 
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700 1 |a Bedaux, J. J. M.  |e verfasserin  |4 aut 
700 1 |a Holst, H.  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Journal of Agricultural, Biological, and Environmental Statistics  |d Springer Science + Business Media  |g 5(2000), 3, Seite 323-341  |w (DE-627)327130652  |w (DE-600)2043957-X  |x 15372693  |7 nnns 
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