Risk of Parkinson's Disease after Hospital Contact for Head Injury: Population Based Case-Control Study

Risk of Parkinson's Disease after Hospital Contact for Head Injury: Population Based Case-Control Study

Objective: To determine whether a hospital contact for a head injury increases the risk of subsequently developing Parkinson's disease. Design: Population based case-control study. Setting: Denmark. Participants: 13 695 patients with a primary diagnosis of Parkinson's disease in the Danish...

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Veröffentlicht in:BMJ: British Medical Journal. - BMJ. - 338(2009), 7685, Seite 34-36
1. Verfasser: Rugbjerg, Kathrine (VerfasserIn)
Weitere Verfasser: Ritz, Beate, Korbo, Lise, Martinussen, Nick, Olsen, Jørgen H.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:BMJ: British Medical Journal
Schlagworte:Health sciences Philosophy Political science Social sciences
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520 |a Objective: To determine whether a hospital contact for a head injury increases the risk of subsequently developing Parkinson's disease. Design: Population based case-control study. Setting: Denmark. Participants: 13 695 patients with a primary diagnosis of Parkinson's disease in the Danish national hospital register during 1986-2006, each matched on age and sex to five population controls selected at random from inhabitants in Denmark alive at the date of the patient's diagnosis (n=68 445). Main outcome measures: Hospital contacts for head injuries ascertained from hospital register; frequency of history of head injury. Results: An overall 50% increase in prevalence of hospital contacts for head injury was seen before the first registration of Parkinson's disease in this population (odds ratio 1.5, 95% confidence interval 1.4 to 1.7). The observed association was, however, due almost entirely to injuries that occurred during the three months before the first record of Parkinson's disease (odds ratio 8.0, 5.6 to 11.6), and no association was found between the two events when they occurred 10 or more years apart (1.1, 0.9 to 1.3). Conclusions: The steeply increased frequency of hospital contacts for a head injury during the months preceding the date at which Parkinson's disease was first recorded is a consequence of the evolving movement disorder rather than its cause. 
540 |a Copyright 2009 BMJ Publishing Group Ltd. 
650 4 |a Health sciences  |x Medical conditions  |x Diseases  |x Nervous system diseases  |x Neurodegenerative diseases  |x Parkinson disease 
650 4 |a Health sciences  |x Medical conditions  |x Physical trauma  |x Nervous system trauma  |x Craniocerebral trauma 
650 4 |a Health sciences  |x Health care industry  |x Health care facilities  |x Hospitals  |x Psychiatric hospitals 
650 4 |a Philosophy  |x Applied philosophy  |x Philosophy of science  |x Scientific method  |x Experimentation  |x Experiment design  |x Longitudinal studies  |x Observational studies  |x Case control studies 
650 4 |a Health sciences  |x Health care industry  |x Health information  |x Biostatistics  |x Health care statistics  |x Hospitalization rates  |x Hospital admissions 
650 4 |a Political science  |x Government  |x Public administration  |x Public policy  |x Social policy  |x Population policy  |x Population control 
650 4 |a Health sciences  |x Health and wellness  |x Public health  |x Epidemiology  |x Disease risk 
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650 4 |a Social sciences  |x Population studies 
650 4 |a Health sciences  |x Medical conditions  |x Diseases  |x Nervous system diseases  |x Neurodegenerative diseases  |x Parkinson disease 
650 4 |a Health sciences  |x Medical conditions  |x Physical trauma  |x Nervous system trauma  |x Craniocerebral trauma 
650 4 |a Health sciences  |x Health care industry  |x Health care facilities  |x Hospitals  |x Psychiatric hospitals 
650 4 |a Philosophy  |x Applied philosophy  |x Philosophy of science  |x Scientific method  |x Experimentation  |x Experiment design  |x Longitudinal studies  |x Observational studies  |x Case control studies 
650 4 |a Health sciences  |x Health care industry  |x Health information  |x Biostatistics  |x Health care statistics  |x Hospitalization rates  |x Hospital admissions 
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650 4 |a Health sciences  |x Medical specialties  |x Neurology 
650 4 |a Health sciences  |x Health and wellness  |x Public health  |x Epidemiology  |x Disease risk  |x Predisposing factors 
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700 1 |a Korbo, Lise  |e verfasserin  |4 aut 
700 1 |a Martinussen, Nick  |e verfasserin  |4 aut 
700 1 |a Olsen, Jørgen H.  |e verfasserin  |4 aut 
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