Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Proteins Research Support, U.S. Gov't, Non-P.H.S. curvature CH index Complex interface Curvature analysis EMDataBank Elasticity Interface Problem Free energy functional Fullerenes High order geometric PDEs Matched interface and boundary Nucleic Acids Protein characterization Protein data bank SC index Validation Study Variational multiscale surfaces anisotropic filtration atomic flexibility coarse-graining electrostatics energy functional filtration fullerene internal cluster validation index isomer