6RS86E2BWQ Autoimmunity Autoinflammation Furans Heterocyclic Compounds, 4 or More Rings IL-1β Indenes Inflammasomes Interleukin-1beta Interleukin-6 Journal Article MCC950 N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 low penetrance mutations NLRP3 protein, human Research Support, Non-U.S. Gov't Sulfonamides Sulfones Tumor Necrosis Factor-alpha