Journal Article 49-00 Broad sense agreement ClinicalTrials.gov identifier: NCT02492568. Corrected loss function Cumulative incidence Double screening Hypothesis testing Latent longitudinal trajectory Left truncation Multilevel modeling Observational studies PTSD Phase II hybrid design Quantile regression Registry data analysis Research Support, Non-U.S. Gov't Time-varying coefficient cost and length of trial optimal weight percent of tumor size change smooth approximation success rate of Phase III trials survival weighted score