Journal Article Research Support, Non-U.S. Gov't Lee‐Richards (accessible) surface Ligands Proteins Voronoi diagram Voronoi diagram of spheres accessible area accessible volume beta-complex beta‐complex beta‐shape conformational space annealing molecular area molecular surface molecular volume offset surface offset‐area offset‐volume protein-ligand docking quasi‐triangulation receptor flexibility solvent accessible surface van der Waals area van der Waals volume