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|a 10.1002/adma.202417869
|2 doi
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|a eng
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|a Jiang, Chaoqing
|e verfasserin
|4 aut
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| 245 |
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|a Microglial-Biomimetic Memantine-Loaded Polydopamine Nanomedicines for Alleviating Depression
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|c 2025
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|a Text
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 02.05.2025
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|a Date Revised 02.05.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 Wiley‐VCH GmbH.
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|a Depression is a common psychiatric disorder, and monoamine-based antidepressants as first-line therapy remain ineffective in some patients. The synergistic modulation of neuroinflammation and neuroplasticity could be a major strategy for treating depression. In this study, an inflammation-targeted microglial biomimetic system, PDA-MemM, is reported for treating depression. Microglial membrane-coated nanoparticles penetrate the blood-brain barrier and facilitate microglial targeting. Subsequently, owing to the excellent free radical-scavenging capacity, PDA-Mem@M attenuate the brain inflammatory microenvironment. After on-demand release from the nanoparticles, memantine increases the expression of brain-derived neurotrophic factors and reverses the loss of synaptic dendritic spines. Further, in vivo studies demonstrate that PDA-Mem@M effectively alleviate depression-like behaviors to a greater extent than memantine or polydopamine nanoparticles (PDA) monotherapy. This synergistic strategy, with satisfactory biosafety and strong anti-inflammatory and synaptic plasticity restoration effects, is conducive to advances in depression therapy
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|a Journal Article
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|a depression
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|a memantine
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|a microglia membrane
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|a polydopamine
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|a Memantine
|2 NLM
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|a W8O17SJF3T
|2 NLM
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|a polydopamine
|2 NLM
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|a Polymers
|2 NLM
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|a Indoles
|2 NLM
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|a Antidepressive Agents
|2 NLM
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|a Drug Carriers
|2 NLM
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| 700 |
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|a Yang, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Qianqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lei, Ting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Hang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Dongxu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Zixiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Yanyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dou, Yikai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Xiaohong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Huile
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 9 vom: 01. März, Seite e2417869
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|g volume:37
|g year:2025
|g number:9
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|g month:03
|g pages:e2417869
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|u http://dx.doi.org/10.1002/adma.202417869
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