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241208s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.pnmrs.2024.05.003
|2 doi
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|a pubmed25n1361.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Dos Santos, Karen
|e verfasserin
|4 aut
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|a Glutamine
|b A key player in human metabolism as revealed by hyperpolarized magnetic resonance
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
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|a ƒa Online-Ressource
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|a Date Completed 07.12.2024
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|a Date Revised 01.04.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
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|a In recent years, there has been remarkable progress in the field of dissolution dynamic nuclear polarization (D-DNP). This method has shown significant potential for enhancing nuclear polarization by over 10,000 times, resulting in a substantial increase in sensitivity. The unprecedented signal enhancements achieved with D-DNP have opened new possibilities for in vitro analysis. This method enables the monitoring of structural and enzymatic kinetics with excellent time resolution at low concentrations. Furthermore, these advances can be straightforwardly translated to in vivo magnetic resonance imaging and magnetic resonance spectroscopy (MRI and MRS) experiments. D-DNP studies have used a range of 13C labeled molecules to gain deeper insights into the cellular metabolic pathways and disease hallmarks. Over the last 15 years, D-DNP has been used to analyze glutamine, a key player in the cellular metabolism, involved in many diseases including cancer. Glutamine is the most abundant amino acid in blood plasma and the major carrier of nitrogen, and it is converted to glutamate inside the cell, where the latter is the most abundant amino acid. It has been shown that increased glutamine consumption by cells is a hallmark of tumor cancer metabolism. In this review, we first highlight the significance of glutamine in metabolism, providing an in-depth description of its use at the cellular level as well as its specific roles in various organs. Next, we present a comprehensive overview of the principles of D-DNP. Finally, we review the state of the art in D-DNP glutamine analysis and its application in oncology, neurology, and perfusion marker studies
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|a Journal Article
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|a Review
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|a Research Support, Non-U.S. Gov't
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|a Glutamine
|2 NLM
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|a 0RH81L854J
|2 NLM
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| 700 |
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|a Bertho, Gildas
|e verfasserin
|4 aut
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| 700 |
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|a Baudin, Mathieu
|e verfasserin
|4 aut
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| 700 |
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|a Giraud, Nicolas
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Progress in nuclear magnetic resonance spectroscopy
|d 1998
|g 144-145(2024) vom: 28. Nov., Seite 15-39
|w (DE-627)NLM098212745
|x 1873-3301
|7 nnas
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|g volume:144-145
|g year:2024
|g day:28
|g month:11
|g pages:15-39
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|u http://dx.doi.org/10.1016/j.pnmrs.2024.05.003
|3 Volltext
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