Insights into the multifaceted role of interleukin-37 on human immune cell regulation

Insights into the multifaceted role of interleukin-37 on human immune cell regulation

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 268(2024) vom: 20. Nov., Seite 110368
1. Verfasser: Teufel, Lisa U (VerfasserIn)
Weitere Verfasser: Matzaraki, Vasiliki, Folkman, Lukas, Ter Horst, Rob, Moorlag, Simone J C F M, Mulders-Manders, Catharina M, Netea, Mihai G, Krausgruber, Thomas, Joosten, Leo A B, Arts, Rob J W
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Autoinflammation BCG Inflammation Interleukin (IL)-37 Trained immunity IL37 protein, human Interleukin-1 Interleukin-6 Interleukins
Beschreibung
Zusammenfassung:Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Autoinflammatory diseases, while having a variety of underlying causes, are mediated by dysfunctional innate immune responses. Therefore, standard treatments target innate cytokines or block their receptors. Despite excellent responses in some patients, first-line treatments fail in others, for reasons which remain to be understood. We studied the effects of IL-37, an anti-inflammatory cytokine, on immune cells using multi-omics profiling of 325 healthy adults. Our findings show that IL-37 is associated with inflammation control and generally reduced immune cell activity. Further, genetic variants in IL37 are associated with impaired trained immunity, a memory phenotype of innate immune cells contributing to autoinflammation. To underpin the medical potential of IL-37, an explorative cohort of seven autoinflammatory disorders was built. In vitro stimulation experiments argue for recombinant IL-37 as a potential therapy in IL-6-, and IL-22-driven conditions. Concluding, IL-37 is highlighted as a cytokine with broad anti-inflammatory functions, implicating its potential as therapeutic intervention
Beschreibung:Date Completed 04.11.2024
Date Revised 07.11.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110368