Salt-Induced Hydrophobic C-Terminal Region of α-Synuclein Triggers Its Fibrillation under the Mimic Physiologic Condition

α-Synuclein (αS) causes Parkinson's disease due to the structural alteration into amyloid fibrils that form after the interaction with synaptic membranes in neurons. To understand the alternation mechanism, the effect of salt (NaCl) on the interaction of αS with synaptic mimic membrane was char...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1999. - 40(2024), 39 vom: 01. Okt., Seite 20537-20549
1. Verfasser: Imaura, Ryota (VerfasserIn)
Weitere Verfasser: Kawata, Yasushi, Matsuo, Koichi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article alpha-Synuclein Sodium Chloride 451W47IQ8X Amyloid