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240816s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202406636
|2 doi
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|a pubmed25n1253.xml
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|a (NLM)39148152
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|a eng
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|a Qian, Lili
|e verfasserin
|4 aut
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|a Self-Adhesive and Self-Sustainable Bioelectronic Patch for Physiological Feedback Electronic Modulation of Soft Organs
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 10.10.2024
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|a Date Revised 10.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Bionic electrical stimulation (Bio-ES) aims to achieve personalized therapy and proprioceptive adaptation by mimicking natural neural signatures of the body, while current Bio-ES devices are reliant on complex sensing and computational simulation systems, thus often limited by the low-fidelity of simulated electrical signals, and failure of interface information interaction due to the mechanical mismatch between soft tissues and rigid electrodes. Here, the study presents a flexible and ultrathin self-sustainable bioelectronic patch (Bio-patch), which can self-adhere to the lesion area of organs and generate bionic electrical signals synchronized vagal nerve envelope in situ to implement Bio-ES. It allows adaptive adjustment of intensity, frequency, and waveform of the Bio-ES to fully meet personalized needs of tissue regeneration based on real-time feedback from the vagal neural controlled organs. With this foundation, the Bio-patch can effectively intervene with excessive fibrosis and microvascular stasis during the natural healing process by regulating the polarization time of macrophages, promoting the reconstruction of the tissue-engineered structure, and accelerating the repair of damaged liver and kidney. This work develops a practical approach to realize biomimetic electronic modulation of the growth and development of soft organs only using a multifunctional Bio-patch, which establishes a new paradigm for precise bioelectronic medicine
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|a Journal Article
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|a bioelectronic patch
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|a biointerfaces
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| 650 |
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|a bionic electrical stimulation
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|a damage repair
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| 650 |
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|a soft tissue engineering
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1 |
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|a Jin, Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Tong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Zhidong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Xiying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Weiying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Javanmardi, Negar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Chengteng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Wei
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Ting
|e verfasserin
|4 aut
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| 700 |
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|a Feng, Zhang-Qi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 41 vom: 16. Okt., Seite e2406636
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:36
|g year:2024
|g number:41
|g day:16
|g month:10
|g pages:e2406636
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|u http://dx.doi.org/10.1002/adma.202406636
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