Injectable and Sprayable Fluorescent Nanoprobe for Rapid Real-Time Detection of Human Colorectal Tumors

Injectable and Sprayable Fluorescent Nanoprobe for Rapid Real-Time Detection of Human Colorectal Tumors

© 2024 Wiley‐VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 36 vom: 19. Sept., Seite e2405275
Auteur principal: Zhang, Bo (Auteur)
Autres auteurs: Lu, Jialiang, Lin, Xu, Wang, Jinqiang, Li, Qi, Jin, Tingting, Shi, Qiuqiu, Lu, Yang, Zhang, Jingyu, Deng, Jun, Zhang, Yinqiong, Guo, Yu, Gao, Jian, Chen, Haifeng, Yan, Youyou, Wu, Jiahe, Gao, Jianqing, Che, Jinxin, Dong, Xiaowu, Gu, Zhen, Lin, Nengming
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article drug delivery image‐guided surgery nanoprobe near‐infrared tumor recognition Fluorescent Dyes NAD(P)H Dehydrogenase (Quinone) EC 1.6.5.2
Description
Résumé:© 2024 Wiley‐VCH GmbH.
The development of minimally invasive surgery has greatly advanced precision tumor surgery, but sometime suffers from restricted visualization of the surgical field, especially during the removal of abdominal tumors. A 3-D inspection of tumors could be achieved by intravenously injecting tumor-selective fluorescent probes, whereas most of which are unable to instantly distinguish tumors via in situ spraying, which is urgently needed in the process of surgery in a convenient manner. In this study, this work has designed an injectable and sprayable fluorescent nanoprobe, termed Poly-g-BAT, to realize rapid tumor imaging in freshly dissected human colorectal tumors and animal models. Mechanistically, the incorporation of γ-glutamyl group facilitates the rapid internalization of Poly-g-BAT, and these internalized nanoprobes can be subsequently activated by intracellular NAD(P)H: quinone oxidoreductase-1 to release near-infrared fluorophores. As a result, Poly-g-BAT can achieve a superior tumor-to-normal ratio (TNR) up to 12.3 and enable a fast visualization (3 min after in situ spraying) of tumor boundaries in the xenograft tumor models, Apcmin/+ mice models and fresh human tumor tissues. In addition, Poly-g-BAT is capable of identifying minimal premalignant lesions via intravenous injection
Description:Date Completed 18.09.2024
Date Revised 18.09.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202405275