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240503s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202401145
|2 doi
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|a pubmed24n1474.xml
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|a (DE-627)NLM371813069
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|a (NLM)38692574
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Liu, Qingsong
|e verfasserin
|4 aut
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|a A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 18.07.2024
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|a Date Revised 18.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Photopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design principle to implement this hypothesis, is proposed. The principle relies on the clamping of cationic moieties (e.g., pyridinium, imidazolium) onto one photosensitive core to facilitate a considerable mitochondrial targeting (both of the inner and the outer membranes) of the molecules, thus maximizing the photogenerated reactive oxygen species (ROS) at the specific site to trigger the gasdermin E-mediated pyroptosis. Through this design, the pyroptotic trigger can be achieved in a minimum of 10 s of irradiation with a substantially low light dosage (0.4 J cm⁻2), compared to relevant work reported (up to 60 J cm⁻2). Moreover, immunotherapy with high tumor inhibition efficiency is realized by applying the synthetic molecules alone. This structural paradigm is valuable for deepening the understanding of PDT (especially the mitochondrial-targeted PDT) from the perspective of pyroptosis, toward the future development of the state-of-the-art form of PDT
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|a Journal Article
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|a cations
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|a immunotherapy
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|a photodynamic therapy
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|a photosensitizers
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|a pyroptosis
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|a Photosensitizing Agents
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Yao, Xianxian
|e verfasserin
|4 aut
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|a Zhou, Lulu
|e verfasserin
|4 aut
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|a Wu, Wenfeng
|e verfasserin
|4 aut
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1 |
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|a Cheng, Jianshuo
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Zexin
|e verfasserin
|4 aut
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| 700 |
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|a Li, Zhongyu
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Hao
|e verfasserin
|4 aut
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| 700 |
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|a Jin, Jian
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Man
|e verfasserin
|4 aut
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|a Wu, Hongwei
|e verfasserin
|4 aut
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|a Zhu, Shihui
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Wuli
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Liangliang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 29 vom: 30. Juli, Seite e2401145
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:29
|g day:30
|g month:07
|g pages:e2401145
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|u http://dx.doi.org/10.1002/adma.202401145
|3 Volltext
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