A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation

A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 29 vom: 30. Juli, Seite e2401145
1. Verfasser: Liu, Qingsong (VerfasserIn)
Weitere Verfasser: Yao, Xianxian, Zhou, Lulu, Wu, Wenfeng, Cheng, Jianshuo, Zhang, Zexin, Li, Zhongyu, Sun, Hao, Jin, Jian, Zhang, Man, Wu, Hongwei, Zhu, Shihui, Yang, Wuli, Zhu, Liangliang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cations immunotherapy photodynamic therapy photosensitizers pyroptosis Photosensitizing Agents Reactive Oxygen Species
Beschreibung
Zusammenfassung:© 2024 Wiley‐VCH GmbH.
Photopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design principle to implement this hypothesis, is proposed. The principle relies on the clamping of cationic moieties (e.g., pyridinium, imidazolium) onto one photosensitive core to facilitate a considerable mitochondrial targeting (both of the inner and the outer membranes) of the molecules, thus maximizing the photogenerated reactive oxygen species (ROS) at the specific site to trigger the gasdermin E-mediated pyroptosis. Through this design, the pyroptotic trigger can be achieved in a minimum of 10 s of irradiation with a substantially low light dosage (0.4 J cm⁻2), compared to relevant work reported (up to 60 J cm⁻2). Moreover, immunotherapy with high tumor inhibition efficiency is realized by applying the synthetic molecules alone. This structural paradigm is valuable for deepening the understanding of PDT (especially the mitochondrial-targeted PDT) from the perspective of pyroptosis, toward the future development of the state-of-the-art form of PDT
Beschreibung:Date Completed 18.07.2024
Date Revised 18.07.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202401145